New Original Paper Published

We are excited to announce that our latest research paper, “Image Sensing of Gaseous Acetone Using Secondary Alcohol Dehydrogenase-Immobilized Mesh for Exhaled Air”, has been published in Analytical Chemistry! This study introduces a highly sensitive and selective method for detecting acetone, a key marker of lipid metabolism, using an enzyme immobilization approach.

Acetone in human breath is an important metabolic indicator, and its precise measurement can provide valuable insights into physiological states such as fasting and fat metabolism. In this study, we developed an immobilization method for secondary alcohol dehydrogenase (S-ADH) and demonstrated its applicability for spatiotemporal imaging of acetone distribution.

Key Findings:

✅ Optimized conditions allowed for high enzymatic activity, enhancing acetone detection sensitivity.

✅ A gas imaging system using the immobilized enzyme successfully visualized acetone distribution in real-time.

✅ The system detected exhaled acetone in fasting individuals, with results consistent with gas chromatography–mass spectrometry (GC-MS).

This method enables real-time imaging and quantification of acetone levels, opening up new possibilities for metabolic monitoring and non-invasive disease screening.

A big thank you to all collaborators who contributed to this work! 🎉

For more details, please check out our full paper here: [Journal Link] 🔗